Repair of oxidative DNA damage in Drosophila melanogaster: identification and characterization of dOgg1, a second DNA glycosylase activity for 8-hydroxyguanine and formamidopyrimidines

In Drosophila, the S3 ribosomal protein has been shown to act as a DNA glycosylase/AP lyase capable of releasing 8-hydroxyguanine (8-OH-Gua) in damaged DNA. Here we describe a second Drosophila protein (dOgg1) with 8-OH-Gua and abasic (AP) site DNA repair activities. The Drosophila OGG1 gene codes f...

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Hlavní autoři: Dherin, Claudine, Dizdaroglu, Miral, Doerflinger, Hélène, Boiteux, Serge, Radicella, J. Pablo
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2000
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC115177/
https://ncbi.nlm.nih.gov/pubmed/11095666
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