Repair of oxidative DNA damage in Drosophila melanogaster: identification and characterization of dOgg1, a second DNA glycosylase activity for 8-hydroxyguanine and formamidopyrimidines

In Drosophila, the S3 ribosomal protein has been shown to act as a DNA glycosylase/AP lyase capable of releasing 8-hydroxyguanine (8-OH-Gua) in damaged DNA. Here we describe a second Drosophila protein (dOgg1) with 8-OH-Gua and abasic (AP) site DNA repair activities. The Drosophila OGG1 gene codes f...

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Detalhes bibliográficos

Publicado no:	Nucleic Acids Res
Principais autores:	Dherin, Claudine, Dizdaroglu, Miral, Doerflinger, Hélène, Boiteux, Serge, Radicella, J. Pablo
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Oxford University Press 2000
Assuntos:	Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC115177/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11095666/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/28.23.4583
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