Mechanism of stimulation of the DNA glycosylase activity of hOGG1 by the major human AP endonuclease: bypass of the AP lyase activity step

The generation of reactive oxygen species in the cell provokes, among other lesions, the formation of 8-oxo-7,8-dihydroguanine (8-oxoG) in DNA. Due to mispairing with adenine during replication, 8-oxoG is highly mutagenic. To minimise the mutagenic potential of this oxidised purine, human cells have...

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Pubblicato in:	Nucleic Acids Res
Autori principali:	Vidal, Antonio E., Hickson, Ian D., Boiteux, Serge, Radicella, J. Pablo
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Oxford University Press 2001
Soggetti:	Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC29755/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11238994/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/29.6.1285
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