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cJun NH(2)-terminal kinase 1 (JNK1): roles in metabolic regulation of insulin resistance
The cJun NH(2)-terminal kinase isoform JNK1 is implicated in the mechanism of obesity-induced insulin resistance. Feeding a high fat diet causes activation of the JNK1 signaling pathway, insulin resistance, and obesity in mice. Germ-line ablation of Jnk1 prevents both diet-induced obesity and insuli...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2010
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2975251/ https://ncbi.nlm.nih.gov/pubmed/20452774 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tibs.2010.04.004 |
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