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Internalization of Aggrecan G1 Domain Neoepitope ITEGE in Chondrocytes Requires CD44

Degradation of the cartilage proteoglycan aggrecan is one of the earliest events that occurs in association with osteoarthritis. Little is known concerning the fate of the residual N-terminal G1 domains of cleaved aggrecan; domains that remain bound to hyaluronan. In this study, 68–72-kDa bands repr...

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Bibliografiska uppgifter
Huvudupphovsmän: Ariyoshi, Wataru, Knudson, Cheryl B., Luo, Na, Fosang, Amanda J., Knudson, Warren
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2010
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Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2975244/
https://ncbi.nlm.nih.gov/pubmed/20843796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.129270
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