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Kinetics and Longevity of ϕC31 Integrase in Mouse Liver and Cultured Cells
The ϕC31 integrase system provides genomic integration of plasmid DNA that may be useful in gene therapy. For example, the ϕC31 system has been used in combination with hydrodynamic injection to achieve long-term expression of factor IX in mouse liver. However, a concern is that prolonged expression...
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| Auteurs principaux: | , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Mary Ann Liebert, Inc.
2010
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2974851/ https://ncbi.nlm.nih.gov/pubmed/20497035 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2010.049 |
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