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Abnormalities in cell proliferation and apico-basal cell polarity are separable in Drosophila lgl mutant clones in the developing eye

In homozygous mutants of Drosophila lethal-2-giant larvae (lgl), tissues lose apico-basal cell polarity and exhibit ectopic proliferation. Here, we use clonal analysis in the developing eye to investigate the effect of lgl null mutations in the context of surrounding wild-type tissue. lgl(−) clones...

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Bibliographische Detailangaben
Hauptverfasser: Grzeschik, Nicola A., Amin, Nancy, Secombe, Julie, Brumby, Anthony M., Richardson, Helena E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2007
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2974846/
https://ncbi.nlm.nih.gov/pubmed/17870065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2007.08.025
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