Combined Statistical Analyses of Peptide Intensities and Peptide Occurrences Improves Identification of Significant Peptides from MS-Based Proteomics Data

[Image: see text] Liquid chromatography−mass spectrometry-based (LC−MS) proteomics uses peak intensities of proteolytic peptides to infer the differential abundance of peptides/proteins. However, substantial run-to-run variability in intensities and observations (presence/absence) of peptides makes...

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Detalhes bibliográficos
Main Authors: Webb-Robertson, Bobbie-Jo M., McCue, Lee Ann, Waters, Katrina M., Matzke, Melissa M., Jacobs, Jon M., Metz, Thomas O., Varnum, Susan M., Pounds, Joel G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2010
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2974810/
https://ncbi.nlm.nih.gov/pubmed/20831241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/pr1005247
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