Review, Evaluation, and Discussion of the Challenges of Missing Value Imputation for Mass Spectrometry-Based Label-Free Global Proteomics

In this review, we apply selected imputation strategies to label-free liquid chromatography–mass spectrometry (LC–MS) proteomics datasets to evaluate the accuracy with respect to metrics of variance and classification. We evaluate several commonly used imputation approaches for individual merits and...

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Detalhes bibliográficos
Publicado no:J Proteome Res
Main Authors: Webb-Robertson, Bobbie-Jo M., Wiberg, Holli K., Matzke, Melissa M., Brown, Joseph N., Wang, Jing, McDermott, Jason E., Smith, Richard D., Rodland, Karin D., Metz, Thomas O., Pounds, Joel G., Waters, Katrina M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4776766/
https://ncbi.nlm.nih.gov/pubmed/25855118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/pr501138h
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