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A Statistical Selection Strategy for Normalization Procedures in LC-MS Proteomics Experiments through Dataset Dependent Ranking of Normalization Scaling Factors

Quantification of LC-MS peak intensities assigned during peptide identification in a typical comparative proteomics experiment will deviate from run-to-run of the instrument due to both technical and biological variation. Thus, normalization of peak intensities across a LC-MS proteomics dataset is a...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Webb-Robertson, Bobbie-Jo M., Matzke, Melissa M., Jacobs, Jon M., Pounds, Joel G., Waters, Katrina M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3517140/
https://ncbi.nlm.nih.gov/pubmed/22038874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pmic.201100078
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