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In several cell types tumour suppressor p53 induces apoptosis largely via Puma but Noxa can contribute
The ability of p53 to induce apoptosis in cells with damaged DNA is thought to contribute greatly to its tumour suppressor function. P53 has been proposed to induce apoptosis via numerous transcriptional targets or even by direct cytoplasmic action. Two transcriptional targets shown to mediate its a...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2974267/ https://ncbi.nlm.nih.gov/pubmed/18259198 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2008.16 |
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