Cyclin D2-CDK4/6 is required for efficient proliferation and tumorigenesis following Apc loss

Inactivation of the Apc gene is recognized as the key early event in the development of sporadic colorectal cancer where its loss leads to constitutive activation of β-catenin/TCF4 signaling and hence transcription of Wnt target genes such as c-Myc. Our and others previous studies have shown that al...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Cole, AM, Myant, K, Reed, KR, Ridgway, RA, Athineos, D, Van den Brink, GR, Muncan, V, Clevers, H, Clarke, AR, Sicinski, P, Sansom, OJ
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2010
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2974087/
https://ncbi.nlm.nih.gov/pubmed/20736363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-0315
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