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Endothelial histamine H(1) receptor signaling reduces blood–brain barrier permeability and susceptibility to autoimmune encephalomyelitis
Disruption of the blood–brain barrier (BBB) underlies the development of experimental autoimmune encephalomyelitis (EAE) and multiple sclerosis. Environmental factors, such as Bordetella pertussis, are thought to sensitize central endothelium to biogenic amines like histamine, thereby leading to inc...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2973887/ https://ncbi.nlm.nih.gov/pubmed/20956310 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1008816107 |
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