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Endothelial histamine H(1) receptor signaling reduces blood–brain barrier permeability and susceptibility to autoimmune encephalomyelitis

Disruption of the blood–brain barrier (BBB) underlies the development of experimental autoimmune encephalomyelitis (EAE) and multiple sclerosis. Environmental factors, such as Bordetella pertussis, are thought to sensitize central endothelium to biogenic amines like histamine, thereby leading to inc...

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Bibliografski detalji
Glavni autori: Lu, Changming, Diehl, Sean A., Noubade, Rajkumar, Ledoux, Jonathan, Nelson, Mark T., Spach, Karen, Zachary, James F., Blankenhorn, Elizabeth P., Teuscher, Cory
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2010
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2973887/
https://ncbi.nlm.nih.gov/pubmed/20956310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1008816107
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