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Single-particle cryoelectron microscopy analysis reveals the HIV-1 spike as a tripod structure
The HIV-1 spike is a trimer of the transmembrane gp41 and the peripheral gp120 subunit pair. It is activated for virus–cell membrane fusion by binding sequentially to CD4 and to a chemokine receptor. Here we have studied the structural transition of the trimeric spike during the activation process....
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Main Authors: | , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
National Academy of Sciences
2010
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2973878/ https://ncbi.nlm.nih.gov/pubmed/20956336 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1007227107 |
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