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Single-particle cryoelectron microscopy analysis reveals the HIV-1 spike as a tripod structure

The HIV-1 spike is a trimer of the transmembrane gp41 and the peripheral gp120 subunit pair. It is activated for virus–cell membrane fusion by binding sequentially to CD4 and to a chemokine receptor. Here we have studied the structural transition of the trimeric spike during the activation process....

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Detalhes bibliográficos
Main Authors: Wu, Shang-Rung, Löving, Robin, Lindqvist, Birgitta, Hebert, Hans, Koeck, Philip J. B., Sjöberg, Mathilda, Garoff, Henrik
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2973878/
https://ncbi.nlm.nih.gov/pubmed/20956336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1007227107
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