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Activation of the Alphavirus Spike Protein Is Suppressed by Bound E3
Alphaviruses are taken up into the endosome of the cell, where acidic conditions activate the spikes for membrane fusion. This involves dissociation of the three E2-E1 heterodimers of the spike and E1 interaction with the target membrane as a homotrimer. The biosynthesis of the heterodimer as a pH-r...
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| 主要な著者: | , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Microbiology
2011
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3094962/ https://ncbi.nlm.nih.gov/pubmed/21430054 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00130-11 |
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