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Structure and mechanism of the complex between cytochrome P4503A4 and ritonavir
Ritonavir is a HIV protease inhibitor routinely prescribed to HIV patients that also potently inactivates cytochrome P4503A4 (CYP3A4), the major human drug-metabolizing enzyme. By inhibiting CYP3A4, ritonavir increases plasma concentrations of other anti-HIV drugs oxidized by CYP3A4 thereby improvin...
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| 主要な著者: | , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2010
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2973003/ https://ncbi.nlm.nih.gov/pubmed/20937904 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1010693107 |
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