A chromatin localization screen reveals poly (ADP ribose)-regulated recruitment of the repressive polycomb and NuRD complexes to sites of DNA damage

Many proteins that respond to DNA damage are recruited to DNA lesions. We used a proteomics approach that coupled isotopic labeling with chromatin fractionation and mass spectrometry to uncover proteins that associate with damaged DNA, many of which are involved in DNA repair or nucleolar function....

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Hauptverfasser: Chou, Danny M., Adamson, Britt, Dephoure, Noah E., Tan, Xu, Nottke, Amanda C., Hurov, Kristen E., Gygi, Steven P., Colaiácovo, Monica P., Elledge, Stephen J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2010
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2972950/
https://ncbi.nlm.nih.gov/pubmed/20937877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1012946107
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