A chromatin localization screen reveals poly (ADP ribose)-regulated recruitment of the repressive polycomb and NuRD complexes to sites of DNA damage

Many proteins that respond to DNA damage are recruited to DNA lesions. We used a proteomics approach that coupled isotopic labeling with chromatin fractionation and mass spectrometry to uncover proteins that associate with damaged DNA, many of which are involved in DNA repair or nucleolar function....

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Main Authors: Chou, Danny M., Adamson, Britt, Dephoure, Noah E., Tan, Xu, Nottke, Amanda C., Hurov, Kristen E., Gygi, Steven P., Colaiácovo, Monica P., Elledge, Stephen J.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2010
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2972950/
https://ncbi.nlm.nih.gov/pubmed/20937877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1012946107
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