Proteasome functional insufficiency activates the calcineurin–NFAT pathway in cardiomyocytes and promotes maladaptive remodelling of stressed mouse hearts

AIMS: Proteasome functional insufficiency (PFI) may play an important role in the progression of congestive heart failure but the underlying molecular mechanism is poorly understood. Calcineurin and nuclear factor of activated T-cells (NFAT) are degraded by the proteasome, and the calcineurin–NFAT p...

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Detalhes bibliográficos
Main Authors: Tang, Mingxin, Li, Jie, Huang, Wei, Su, Huabo, Liang, Qiangrong, Tian, Zongwen, Horak, Kathleen M., Molkentin, Jeffery D., Wang, Xuejun
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2010
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2972684/
https://ncbi.nlm.nih.gov/pubmed/20601385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvq217
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