Proteasome functional insufficiency activates the calcineurin–NFAT pathway in cardiomyocytes and promotes maladaptive remodelling of stressed mouse hearts

AIMS: Proteasome functional insufficiency (PFI) may play an important role in the progression of congestive heart failure but the underlying molecular mechanism is poorly understood. Calcineurin and nuclear factor of activated T-cells (NFAT) are degraded by the proteasome, and the calcineurin–NFAT p...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Tang, Mingxin, Li, Jie, Huang, Wei, Su, Huabo, Liang, Qiangrong, Tian, Zongwen, Horak, Kathleen M., Molkentin, Jeffery D., Wang, Xuejun
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2010
Assuntos:
Original Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2972684/
https://ncbi.nlm.nih.gov/pubmed/20601385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvq217
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares