Doxycycline Attenuates Protein Aggregation in Cardiomyocytes and Improves Survival of a Mouse Model of Cardiac Proteinopathy

OBJECTIVE: The goal of this preclinical study was to assess the therapeutic efficacy of doxycycline (Doxy) for desmin-related cardiomyopathy (DRC) and to elucidate the potential mechanisms involved. BACKGROUND: DRC, exemplifying cardiac proteinopathy, is characterized by intrasarcoplasmic protein ag...

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Autores principales: Zheng, Hanqiao, Tang, Mingxin, Zheng, Qingwen, Kumarapeli, Asangi R. K., Horak, Kathleen M., Tian, Zongwen, Wang, Xuejun
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2964264/
https://ncbi.nlm.nih.gov/pubmed/20947000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacc.2010.01.075
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