Genetically induced moderate inhibition of 20S proteasomes in cardiomyocytes facilitates heart failure in mice during systolic overload

The in vivo function status of the ubiquitin-proteasome system (UPS) in pressure overloaded hearts remains undefined. Cardiotoxicity was observed during proteasome inhibitor chemotherapy, especially in those with preexisting cardiovascular conditions; however, proteasome inhibition (PsmI) was also s...

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Vydáno v:J Mol Cell Cardiol
Hlavní autoři: Ranek, Mark J., Zheng, Hanqiao, Huang, Wei, Kumarapeli, Asangi R., Li, Jie, Liu, Jinbao, Wang, Xuejun
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4530032/
https://ncbi.nlm.nih.gov/pubmed/26116868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2015.06.014
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