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Doxycycline Attenuates Protein Aggregation in Cardiomyocytes and Improves Survival of a Mouse Model of Cardiac Proteinopathy
OBJECTIVE: The goal of this preclinical study was to assess the therapeutic efficacy of doxycycline (Doxy) for desmin-related cardiomyopathy (DRC) and to elucidate the potential mechanisms involved. BACKGROUND: DRC, exemplifying cardiac proteinopathy, is characterized by intrasarcoplasmic protein ag...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2010
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2964264/ https://ncbi.nlm.nih.gov/pubmed/20947000 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacc.2010.01.075 |
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