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Activation of the Cystic Fibrosis Transmembrane Conductance Regulator by the Flavonoid Quercetin: Potential Use as a Biomarker of ΔF508 Cystic Fibrosis Transmembrane Conductance Regulator Rescue

Therapies to correct the ΔF508 cystic fibrosis transmembrane conductance regulator (CFTR) folding defect require sensitive methods to detect channel activity in vivo. The β(2) adrenergic receptor agonists, which provide the CFTR stimuli commonly used in nasal potential difference assays, may not ove...

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Главные авторы: Pyle, Louise C., Fulton, Jennifer C., Sloane, Peter A., Backer, Kyle, Mazur, Marina, Prasain, Jeevan, Barnes, Stephen, Clancy, J. P., Rowe, Steven M.
Формат: Artigo
Язык:Inglês
Опубликовано: American Thoracic Society 2010
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2970857/
https://ncbi.nlm.nih.gov/pubmed/20042712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2009-0281OC
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