A Phase I Study of a Tropism Modified Conditionally Replicative Adenovirus (CRAd) for Recurrent Gynecologic Malignancies

PURPOSE: To determine the maximum tolerated dose (MTD), toxicity spectrum, clinical activity, and biological effects of the tropism-modified infectivity-enhanced CRAd, Ad5-Δ24-RGD, in patients with gynecologic malignancies. EXPERIMENTAL DESIGN: Cohorts of eligible patients were treated daily for 3 d...

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Détails bibliographiques
Auteurs principaux: Kimball, Kristopher J., Preuss, Meredith A., Barnes, Mack N., Wang, Minghui, Siegal, Gene P., Wan, Wen, Kuo, Huichien, Saddekni, Souheil, Stockard, Cecil R., Grizzle, William E., Harris, Raymond D., Aurigemma, Rosemarie, Curiel, David T., Alvarez, Ronald D.
Format: Artigo
Langue:Inglês
Publié: 2010
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2970766/
https://ncbi.nlm.nih.gov/pubmed/20978148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-10-0791
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