A Phase I Study of a Tropism Modified Conditionally Replicative Adenovirus (CRAd) for Recurrent Gynecologic Malignancies

PURPOSE: To determine the maximum tolerated dose (MTD), toxicity spectrum, clinical activity, and biological effects of the tropism-modified infectivity-enhanced CRAd, Ad5-Δ24-RGD, in patients with gynecologic malignancies. EXPERIMENTAL DESIGN: Cohorts of eligible patients were treated daily for 3 d...

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Detaylı Bibliyografya
Asıl Yazarlar: Kimball, Kristopher J., Preuss, Meredith A., Barnes, Mack N., Wang, Minghui, Siegal, Gene P., Wan, Wen, Kuo, Huichien, Saddekni, Souheil, Stockard, Cecil R., Grizzle, William E., Harris, Raymond D., Aurigemma, Rosemarie, Curiel, David T., Alvarez, Ronald D.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2010
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2970766/
https://ncbi.nlm.nih.gov/pubmed/20978148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-10-0791
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