Definition of ubiquitination modulator COP1 as a novel therapeutic target in human hepatocellular carcinoma

Development of targeted therapeutics for hepatocellular carcinoma (HCC) remains a major challenge. The ubiquitination modulator COP1 regulates p53 activity by ubiquitination and it is frequently overexpressed in human HCC. In this study we tested the hypothesis that COP1 blockade by siRNA-mediated i...

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Autors principals: Lee, Yun-Han, Andersen, Jesper B., Song, Ho-Taek, Judge, Adam D., Seo, Daekwan, Ishikawa, Tsuyoshi, Marquardt, Jens U., Kitade, Mitsuteru, Durkin, Marian, Raggi, Chiara, Woo, Hyun Goo, Conner, Elizabeth A., Avital, Itzhak, MacLachlan, Ian, Factor, Valentina M., Thorgeirsson, Snorri S.
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2970744/
https://ncbi.nlm.nih.gov/pubmed/20959491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-0749
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