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β-amyloid regulates leptin expression and tau phosphorylation through the mTORC1 signaling pathway
High levels of the adipocytokine leptin are associated with reduced risk of Alzheimer’s disease (AD). Leptin treatment also reduces β-amyloid (Aβ) levels in in vivo and in vitro models of AD. Aβ and leptin interact with the Akt/mammalian target of rapamycin complex1 (mTORC1) signaling pathway. Akt/m...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2970652/ https://ncbi.nlm.nih.gov/pubmed/20670375 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2010.06929.x |
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