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Leptin Reduces the Accumulation of Aβ and Phosphorylated Tau Induced by 27-Hydroxycholesterol in Rabbit Organotypic Slices

Accumulation of amyloid-β (Aβ) peptide and deposition of hyperphosphorylated tau protein are two major pathological hallmarks of Alzheimer’s disease (AD). We have shown that cholesterol-enriched diets and its metabolite 27-hydroxycholesterol (27-OHC) increase Aβ and phosphorylated tau levels. Howeve...

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Detalhes bibliográficos
Main Authors: Marwarha, Gurdeep, Dasari, Bhanu, Prasanthi, Jaya R.P., Schommer, Jared, Ghribi, Othman
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2924284/
https://ncbi.nlm.nih.gov/pubmed/20157255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-2010-1298
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