The oxysterol 27-hydroxycholesterol increases β-amyloid and oxidative stress in retinal pigment epithelial cells

BACKGROUND: Alzheimer's disease (AD) and age-related macular degeneration (AMD) share several pathological features including β-amyloid (Aβ) peptide accumulation, oxidative damage, and cell death. The causes of AD and AMD are not known but several studies suggest disturbances in cholesterol met...

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Hlavní autoři: Dasari, Bhanu, Prasanthi, Jaya RP, Marwarha, Gurdeep, Singh, Brij B, Ghribi, Othman
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2010
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2946278/
https://ncbi.nlm.nih.gov/pubmed/20836858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2415-10-22
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