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A radical explanation for glucose-induced β cell dysfunction

The development of type 2 diabetes requires impaired β cell function. Hyperglycemia itself causes further decreases in glucose-stimulated insulin secretion. A new study demonstrates that hyperglycemia-induced mitochondrial superoxide production activates uncoupling protein 2, which decreases the ATP...

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Detalhes bibliográficos
Autor principal: Brownlee, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC297003/
https://ncbi.nlm.nih.gov/pubmed/14679173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200320501
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