Overexpression of Kinase-Negative Protein Kinase Cδ in Pancreatic β-Cells Protects Mice From Diet-Induced Glucose Intolerance and β-Cell Dysfunction

OBJECTIVE: In vitro models suggest that free fatty acid–induced apoptotic β-cell death is mediated through protein kinase C (PKC)δ. To examine the role of PKCδ signaling in vivo, transgenic mice overexpressing a kinase-negative PKCδ (PKCδKN) selectively in β-cells were generated and analyzed for glu...

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Hauptverfasser: Hennige, Anita M., Ranta, Felicia, Heinzelmann, Isabel, Düfer, Martina, Michael, Diana, Braumüller, Heidi, Lutz, Stefan Z., Lammers, Reiner, Drews, Gisela, Bosch, Fatima, Häring, Hans-Ulrich, Ullrich, Susanne
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Diabetes Association 2010
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2797912/
https://ncbi.nlm.nih.gov/pubmed/19826167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db09-0512
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