Carcinoma in situ testis displays permissive chromatin modifications similar to immature foetal germ cells

BACKGROUND: The majority of testicular germ cell cancers develop through a pre-invasive carcinoma in situ (CIS) stage. The CIS cell is a neoplastic counterpart of foetal germ cells. During their development, foetal germ cells undergo extensive and essential epigenetic modifications, but little is kn...

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Bibliographische Detailangaben
Hauptverfasser: Almstrup, K, Nielsen, J E, Mlynarska, O, Jansen, M T, Jørgensen, A, Skakkebæk, N E, Rajpert-De Meyts, E
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2010
Schlagworte:
Genetics and Genomics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2967056/
https://ncbi.nlm.nih.gov/pubmed/20823885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605880
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