Ex vivo culture of human fetal gonads: Manipulation of meiosis signalling by retinoic acid treatment disrupts testis development

STUDY QUESTION: What are the effects of experimentally manipulating meiosis signaling by addition of retinoic acid (RA) in cultured human fetal gonads? SUMMARY ANSWER: RA-treatment accelerated meiotic entry in cultured fetal ovary samples, while addition of RA resulted in a dysgenetic gonadal phenot...

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Gepubliceerd in:Hum Reprod
Hoofdauteurs: Jørgensen, A, Nielsen, JE, Perlman, S, Lundvall, L, Mitchell, RT, Juul, A, Rajpert-De Meyts, E
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5513102/
https://ncbi.nlm.nih.gov/pubmed/26251460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/humrep/dev194
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