Transferrin receptor 2 and HFE regulate furin expression via mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/Erk) signaling. Implications for transferrin-dependent hepcidin regulation

BACKGROUND: Impaired regulation of hepcidin in response to iron is the cause of genetic hemochromatosis associated with defects of HFE and transferrin receptor 2. However, the role of these proteins in the regulation of hepcidin expression is unclear. DESIGN AND METHODS: Hepcidin expression, SMAD an...

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Hlavní autoři: Poli, Maura, Luscieti, Sara, Gandini, Valentina, Maccarinelli, Federica, Finazzi, Dario, Silvestri, Laura, Roetto, Antonella, Arosio, Paolo
Médium: Artigo
Jazyk:Inglês
Vydáno: Ferrata Storti Foundation 2010
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2966904/
https://ncbi.nlm.nih.gov/pubmed/20634490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2010.027003
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