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Hepcidin antagonists for potential treatments of disorders with hepcidin excess
The discovery of hepcidin clarified the basic mechanism of the control of systemic iron homeostasis. Hepcidin is mainly produced by the liver as a propeptide and processed by furin into the mature active peptide. Hepcidin binds ferroportin, the only cellular iron exporter, causing the internalizatio...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Frontiers Media S.A.
2014
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4009444/ https://ncbi.nlm.nih.gov/pubmed/24808863 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2014.00086 |
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