Hepatic heparan sulfate is a master regulator of hepcidin expression and iron homeostasis in human hepatocytes and mice

Hepcidin is a liver-derived peptide hormone that controls systemic iron homeostasis. Its expression is regulated by the bone morphogenetic protein 6 (BMP6)/SMAD1/5/8 pathway and by the proinflammatory cytokine interleukin 6 (IL6). Proteoglycans that function as receptors of these signaling proteins...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Poli, Maura, Anower-E-Khuda, Ferdous, Asperti, Michela, Ruzzenenti, Paola, Gryzik, Magdalena, Denardo, Andrea, Gordts, Philip L. S. M., Arosio, Paolo, Esko, Jeffrey D.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2019
Matèries:
Cell Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6737225/
https://ncbi.nlm.nih.gov/pubmed/31315930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.007213
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