Msh6 Protects Mature B Cells from Lymphoma by Preserving Genomic Stability

Most human B-cell non-Hodgkin’s lymphomas arise from germinal centers. Within these sites, the mismatch repair factor MSH6 participates in antibody diversification. Reminiscent of the neoplasms arising in patients with Lynch syndrome III, mice deficient in MSH6 die prematurely of lymphoma. In this s...

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Detalhes bibliográficos
Main Authors: Peled, Jonathan U., Sellers, Rani S., Iglesias-Ussel, Maria D., Shin, Dong-Mi, Montagna, Cristina, Zhao, Chunfang, Li, Ziqiang, Edelmann, Winfried, Morse, Herbert C., Scharff, Matthew D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2010
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2966815/
https://ncbi.nlm.nih.gov/pubmed/20934970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.100234
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