Msh6 Protects Mature B Cells from Lymphoma by Preserving Genomic Stability

Most human B-cell non-Hodgkin’s lymphomas arise from germinal centers. Within these sites, the mismatch repair factor MSH6 participates in antibody diversification. Reminiscent of the neoplasms arising in patients with Lynch syndrome III, mice deficient in MSH6 die prematurely of lymphoma. In this s...

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Bibliografiske detaljer
Main Authors: Peled, Jonathan U., Sellers, Rani S., Iglesias-Ussel, Maria D., Shin, Dong-Mi, Montagna, Cristina, Zhao, Chunfang, Li, Ziqiang, Edelmann, Winfried, Morse, Herbert C., Scharff, Matthew D.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Investigative Pathology 2010
Fag:
Regular Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2966815/
https://ncbi.nlm.nih.gov/pubmed/20934970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.100234
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