Development of Sporadic Microsatellite Instability in Colorectal Tumors Involves Hypermethylation at Methylated-In-Tumor Loci in Adenoma

Microsatellite instability (MSI) and genomic hypermethylation of methylated-in-tumor (MINT) loci are both strong prognostic indicators in a subgroup of patients with sporadic colorectal cancer (CRC). The present study was designed to determine whether the methylation of MINT loci during the progress...

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Detalhes bibliográficos
Main Authors: de Maat, Michiel F.G., Narita, Norihiko, Benard, Anne, Yoshimura, Tetsunori, Kuo, Christine, Tollenaar, Rob A.E.M., de Miranda, Noel F.C.C., Turner, Roderick R., van de Velde, Cornelis J.H., Morreau, Hans, Hoon, Dave S.B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2010
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2966793/
https://ncbi.nlm.nih.gov/pubmed/20952593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.091103
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