HNPCC versus sporadic microsatellite-unstable colon cancers follow different routes toward loss of HLA class I expression

BACKGROUND: Abnormalities in Human Leukocyte Antigen (HLA) class I expression are common in colorectal cancer. Since HLA expression is required to activate tumor antigen-specific cytotoxic T-lymphocytes (CTL), HLA class I abnormalities represent a mechanism by which tumors circumvent immune surveill...

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Detalhes bibliográficos
Main Authors: Dierssen, Jan Willem F, de Miranda, Noel FCC, Ferrone, Soldano, van Puijenbroek, Marjo, Cornelisse, Cees J, Fleuren, Gert Jan, van Wezel, Tom, Morreau, Hans
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2007
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1808468/
https://ncbi.nlm.nih.gov/pubmed/17316446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-7-33
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