Integrin β(3) Phosphorylation Dictates Its Complex with the Shc Phosphotyrosine-binding (PTB) Domain

Adaptor protein Shc plays a key role in mitogen-activated protein kinase (MAPK) signaling pathway, which can be mediated through a number of different receptors including integrins. By specifically recognizing the tyrosine-phosphorylated integrin β(3), Shc has been shown to trigger integrin outside-...

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Bibliographic Details
Main Authors: Deshmukh, Lalit, Gorbatyuk, Vitaliy, Vinogradova, Olga
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2010
Subjects:
Protein Structure and Folding
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2966102/
https://ncbi.nlm.nih.gov/pubmed/20739287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.159087
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