A Key Role for the Phosphorylation of Ser(440) by the Cyclic AMP-dependent Protein Kinase in Regulating the Activity of the Src Homology 2 Domain-containing Inositol 5′-Phosphatase (SHIP1)

The Src homology 2 domain-containing inositol 5′-phosphatase 1 (SHIP1) dephosphorylates phosphatidylinositol 3,4,5-trisphosphate to phophatidylinositol 3,4-bisphosphate in hematopoietic cells to regulate multiple cell signaling pathways. SHIP1 can be phosphorylated by the cyclic AMP-dependent protei...

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Hlavní autoři: Zhang, Jun, Ravichandran, Kodi S., Garrison, James C.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2010
Témata:
Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2966099/
https://ncbi.nlm.nih.gov/pubmed/20810657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.128827
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