Altered Glucose Homeostasis in Mice with Liver-specific Deletion of Src Homology Phosphatase 2

The Src homology 2 domain-containing protein-tyrosine phosphatase Shp2 has been implicated in a variety of growth factor signaling pathways, but its role in insulin signaling has remained unresolved. In vitro studies suggest that Shp2 is both a negative and positive regulator of insulin signaling, a...

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Detalhes bibliográficos
Main Authors: Matsuo, Kosuke, Delibegovic, Mirela, Matsuo, Izumi, Nagata, Naoto, Liu, Siming, Bettaieb, Ahmed, Xi, Yannan, Araki, Kazushi, Yang, Wentian, Kahn, Barbara B., Neel, Benjamin G., Haj, Fawaz G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3000956/
https://ncbi.nlm.nih.gov/pubmed/20841350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.153734
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