A Dual Role for Src Homology 2 Domain–Containing Inositol-5-Phosphatase (Ship) in Immunity: Aberrant Development and Enhanced Function of B Lymphocytes in Ship(−/)− Mice

In this report, we demonstrate that the Src homology 2 domain–containing inositol-5-phosphatase (SHIP) plays a critical role in regulating both B cell development and responsiveness to antigen stimulation. SHIP(−/−) mice exhibit a transplantable alteration in B lymphoid development that results in r...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Helgason, Cheryl D., Kalberer, Christian P., Damen, Jacqueline E., Chappel, Suzanne M., Pineault, Nicolas, Krystal, Gerald, Humphries, R. Keith
Formato: Artigo
Idioma:Inglês
Publicado: The Rockefeller University Press 2000
Assuntos:
Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2195854/
https://ncbi.nlm.nih.gov/pubmed/10704460
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares