Factor X/Xa Elicits Protective Signaling Responses in Endothelial Cells Directly via PAR-2 and Indirectly via Endothelial Protein C Receptor-dependent Recruitment of PAR-1

We recently demonstrated that the Gla domain-dependent interaction of protein C with endothelial protein C receptor (EPCR) leads to dissociation of the receptor from caveolin-1 and recruitment of PAR-1 to a protective signaling pathway. Thus, the activation of PAR-1 by either thrombin or PAR-1 agoni...

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Bibliografske podrobnosti
Main Authors: Bae, Jong-Sup, Yang, Likui, Rezaie, Alireza R.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2010
Teme:
Signal Transduction
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2966096/
https://ncbi.nlm.nih.gov/pubmed/20826780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.163642
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