NHE3 Activity Is Dependent on Direct Phosphoinositide Binding at the N Terminus of Its Intracellular Cytosolic Region

The small intestinal BB Na(+)/H(+) antiporter NHE3 accounts for the majority of intestinal sodium and water absorption. It is highly regulated with both postprandial inhibition and stimulation sequentially occurring. Phosphatidylinositide 4,5-bisphosphate (PI(4,5)P(2)) and phosphatidylinositide 3,4,...

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Detalhes bibliográficos
Main Authors: Mohan, Sachin, Tse, Chung Ming, Gabelli, Sandra B., Sarker, Rafiquel, Cha, Boyoung, Fahie, Kamau, Nadella, Mythili, Zachos, Nicholas C., Tu-Sekine, Becky, Raben, Daniel, Amzel, L. Mario, Donowitz, Mark
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2966072/
https://ncbi.nlm.nih.gov/pubmed/20736165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.165712
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