Genome-wide erasure of DNA methylation in mouse primordial germ cells is affected by Aid deficiency

Epigenetic reprogramming including demethylation of DNA occurs in mammalian primordial germ cells (PGCs) and in early embryos, and is important for the erasure of imprints and epimutations, and the return to pluripotency1-9. The extent of this reprogramming and its molecular mechanisms are poorly un...

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Huvudupphovsmän: Popp, Christian, Dean, Wendy, Feng, Suhua, Cokus, Shawn J., Andrews, Simon, Pellegrini, Matteo, Jacobsen, Steven E., Reik, Wolf
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2010
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2965733/
https://ncbi.nlm.nih.gov/pubmed/20098412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature08829
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