Genome-wide erasure of DNA methylation in mouse primordial germ cells is affected by Aid deficiency

Epigenetic reprogramming including demethylation of DNA occurs in mammalian primordial germ cells (PGCs) and in early embryos, and is important for the erasure of imprints and epimutations, and the return to pluripotency1-9. The extent of this reprogramming and its molecular mechanisms are poorly un...

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Bibliographic Details
Main Authors: Popp, Christian, Dean, Wendy, Feng, Suhua, Cokus, Shawn J., Andrews, Simon, Pellegrini, Matteo, Jacobsen, Steven E., Reik, Wolf
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2965733/
https://ncbi.nlm.nih.gov/pubmed/20098412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature08829
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