Antidotes to anthrax lethal factor intoxication. Part 1: Discovery of potent lethal factor inhibitors with in vivo efficacy

Sub-nanomolar small molecule inhibitors of anthrax lethal factor have been identified using SAR and Merck L915 (4) as a model compound. One of these compounds (16) provided 100% protection in a rat lethal toxin model of anthrax disease.

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Bibliografiske detaljer
Main Authors:	Jiao, Guan-Sheng, Kim, Seongjin, Moayeri, Mahtab, Cregar-Hernandez, Lynne, McKasson, Linda, Margosiak, Stephen A., Leppla, Stephen H., Johnson, Alan T.
Format:	Artigo
Sprog:	Inglês
Udgivet:	2010
Fag:	Article
Online adgang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2965585/ https://ncbi.nlm.nih.gov/pubmed/20864339 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2010.08.058
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Antidotes to anthrax lethal factor intoxication. Part 1: Discovery of potent lethal factor inhibitors with in vivo efficacy

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