Fibulin-1 is required for morphogenesis of neural crest-derived structures

Here we report that mouse embryos homozygous for a gene trap insertion in the fibulin-1 (Fbln1) gene are deficient in Fbln1 and exhibit cardiac ventricular wall thinning and ventricular septal defects with double outlet right ventricle or overriding aorta. Fbln1 nulls also display anomalies of aorti...

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Autors principals: Cooley, Marion A., Kern, Christine B., Fresco, Victor M., Wessels, Andy, Thompson, Robert P., McQuinn, Tim C., Twal, Waleed O., Mjaatvedt, Corey H., Drake, Christopher J., Argraves, W. Scott
Format: Artigo
Idioma:Inglês
Publicat: 2008
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2965525/
https://ncbi.nlm.nih.gov/pubmed/18538758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2008.04.029
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